Transcriptional regulation of mammalian selenoprotein expression

Mammalian Selenoprotein Thioredoxin-glutathione Reductase

Gene-specific regulation of hepatic selenoprotein expression by interleukin-6.

Sepsis is a severe inflammatory disease resulting in excessive production of pro-inflammatory cytokines including interleukin-6 (IL-6), causing oxidative stress, tissue damage and organ dysfunction. Health benefits have been observed upon selenium (Se) supplementation in severe sepsis. Selenium is incorporated into selenoproteins implicated in anti-oxidative defence, thyroid hormone metabolism ...

Regulation of selenoprotein gene expression and thyroid hormone metabolism.

28 Alessi, D. R., Smythe, C. and Keyse, S. M. (1993) Oncogene 8,2015-2020 29 Stumpo, D. J., Stewart, T. N., Gilman, N. 2. and Blackshear, P. J. (1988) J. Biol. Chem. 263, 16111614 30 Pulverer, B. J., Kyriakis, J. M., Avruch, J., Nikolakaki, E. and Woodgett, J. R. (1991) Nature (London) 353,670-674 31 Derjard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R. J. (19...

Selenoprotein W expression and regulation in mouse brain and neurons

Background Selenoprotein W (Sepw1) is a selenium-containing protein that is abundant in brain and muscle of vertebrate animals. Muscular expression of Sepw1 is reduced by dietary selenium (Se) deficiency in mammals, whereas brain expression is maintained. However, expression of Sepw1 depends on the Se transporter selenoprotein P (Sepp1). Methods We assessed the regional and cellular expression ...

Transcriptional Regulation of CYP2D6 Expression.

CYP2D6-mediated drug metabolism exhibits large interindividual variability. Although genetic variations in the CYP2D6 gene are well known contributors to the variability, the sources of CYP2D6 variability in individuals of the same genotype remain unexplained. Accumulating data indicate that transcriptional regulation of CYP2D6 may account for part of CYP2D6 variability. Yet, our understanding ...